ProHeart 6 is an injectable medication that is used in dogs 6 months of age or older to prevent heartworm disease. Your veterinarian will administer ProHeart 6 as a single injection under your dog’s skin. Once the drug is given, it continuously prevents heartworm disease for 6 months. Using ProHeart 6 means that you don’t need to …May 21, 2021 ... immitis for 6 or 12 months (ProHeart R 6 or ProHeart R ... A dog was defined as compliant with extended release moxidectin dosing if it received a ...It’s available in four dosing sizes (2-8 lbs., 8.1-25 lbs., 25.1-50 lbs., and 50.1-100 lbs.). Dogs over 100 pounds can still take this medication but will require a combination of chewables for appropriate dosing. Dogs must be at least 2 pounds in size and 6 weeks or older to take this prevention. Simparica TrioA once yearly proheart injection, is very affordable and is the absolute gold standard in heartworm prevention worldwide. Why monthly dosing is a risky option. Recent survey studies conducted in the United States have revealed that of those patients not receiving the annual Proheart heartworm injection, only 75% are on a monthly preventative.ProHeart 12 prevents the development of heartworm disease caused by D. immitis for 12 months. For dogs not previously on heartworm preventive or having lapsed beyond 12 months of a prior ProHeart 12 dose, the product should be given within 1 month of exposure to mosquitoes. Follow-up treatments may be given every 12 months,heartworm preventive product, ProHeart 6 should be given within one month of the last dose of the former medication. ProHeart 6 eliminates the larval and adult stages of A. caninum and U. stenocephala present at the time of treatment. However, persistent effectiveness has not been established for this indication. Re-infection with A. caninum andProHeart 6 is indicated for use in dogs six months of age and older for the prevention of heartworm disease caused by Dirofilaria immitis for 6 months. ProHeart 6 is indicated for the treatment of existing larval and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections. DOSAGE AND ADMINISTRATIONProHeart 12 is an extended-release injectable formulation of moxidectin for dogs 12 months of age or older. It protects against heartworm disease and other parasites for 12 months with one dose.ProHeart offers convenience with less frequent dosing, while Simparica Trio appeals to those who prefer oral administration. Round 3: Safety and Side Effects Both medications have demonstrated safety in numerous studies, but as with all treatments, side effects can occur.Use with caution in cats with a history of neurologic disorders. Sarolaner, one of the ingredients in Revolution Plus, is a member of the isoxazoline class, which has been associated with adverse reactions such as tremors, ataxia, and seizures. Reactions have occurred in cats with or without a history of neurologic disorders.Passos para a diluição do ProHeart SR-12In a well-controlled 605-day US field study, two doses of ProHeart 12 were administered subcutaneously at a dosage of 0.5 mg/kg (0.23 mg/lb), 12 months apart. A total of 235, 226 and 222 ProHeart 12-treated dogs completed the heartworm testing (adult heartworm antigen and microfilariae) on Days 365, 480 and 605, respectively.Diroban is for use in dogs only. Do not use in dogs with very severe (Class 4) heartworm disease. Avoid human exposure. Consult a physician in cases of accidental human exposure by any route. Diroban should be administered by deep intramuscular injection in the lumbar (epaxial) muscles (L3–L5) only. Do not use in any other muscle group.Compliance ProHeart 12 provides 12 months of guaranteed heartworm disease prevention compliance in a single dose. ProHeart 12 provides dog owners with peace of mind and convenience, as once-yearly doses align with regular veterinary wellness visits.ProHeart 12 is indicated for use in dogs 12 months of age and older for the accurate dosing calculate each dose based on the dog's weight at the time ... proheart pi ProHeart® 6(moxidectin) ProHeart 6 is indicated for use in dogs six months of age and older for the calculate each dose based on the dog's weight at the time of treatment. proheartcis piPurpose: To determine the effects on dogs of prolonged administration of moxidectin tablets at ten times the recommended an elevated dose. Animals: Two collies (1 male, 1 female), eight weeks of age. Dosage form: tablets. Dose Levels and Regimen: moxidectin was administered at 30 mcg /kg body weight for twelve days.Extended Protection: ProHeart 6 provides six months of continuous heartworm disease prevention, while ProHeart 12 offers a full year of coverage. Convenience: A single injection eliminates the need for monthly reminders. Veterinarian-Administered: Ensures proper dosage and offers an opportunity for a health check-up.Heartgard: The Monthly Protector. Heartgard is a monthly oral medication that prevents heartworm disease, as well as treats and controls roundworms and hookworms. Key Benefits: Monthly dosing: Allows for flexibility and ease of discontinuation if necessary. Palatable chew: Dogs often see it as a treat, making administration easy.Methods Study 1: safety margin was evaluated as 3 treatments of PH 12 (0× (control); 1× (recommended dose); 3× (3 times recommended dose) and 5× (5 times recommended dose) in 12 months via clinical observations, body weights, food consumption, injection site observations, physical examinations, moxidectin tissue assay, …Sep 6, 2019 · Over the past 11 years an estimated 12.4 million doses have been distributed there. More recently, PH 12 is also being marketed in a number of Asian and Latin American countries. In the USA, ProHeart ® 6 (PH 6) employs the same microsphere suspension as PH 12 at a lower dosage that protects against heartworm disease for 6 months. Shortly after ... 0.50 mg ProHeart 6/kg bodyweight (high-dose) Route of Administration: Subcutaneous injection in the dorsum of the neck. Test Duration: 327 days (treatment to necropsy). Study Design: All dogs were determined to be negative for D. immitis by antigen test and modified Knott’s test prior to study initiation.The lethal dose of diphenhydramine, the generic name of Benadryl, varies significantly from person to person because of differences in weight and metabolism.A single dose of ProHeart® 12 was 100% effective in preventing heartworm disease in dogs for a full year in both laboratory and field studies. Background: The efficacy of an extended-release injectable moxidectin (0.5 mg/kg) suspension (ProHeart® 12) (PH 12) in preventing the development of Dirofilaria immitis in dogs for 12 months was …It’s available in four dosing sizes (2-8 lbs., 8.1-25 lbs., 25.1-50 lbs., and 50.1-100 lbs.). Dogs over 100 pounds can still take this medication but will require a combination of chewables for appropriate dosing. Dogs must be at least 2 pounds in size and 6 weeks or older to take this prevention. Simparica TrioProHeart 12 Dosing Chart ProHeart 12 vs. Heartgard for Dogs 🐾 Category: Toxicity Published on: March 28, 2024 March 28, 2024 Author: Bestie Paws Like: 26 Comment: 0 Leave a Reply Cancel reply Your email …ProHeart 6 administered at 3 times the recommended dose did not adversely affect the reproductive performance of male or female dogs. ProHeart 6 administered up to 5 times the recommended dose in 7-8 month old puppies did … heartworm preventive product, ProHeart 6 should be given within one month of the last dose of the former medication. ProHeart 6 eliminates the larval and adult stages of A. caninum and U. stenocephala present at the time of treatment. However, persistent effectiveness has not been established for this indication. Re-infection with A. caninum and Jul 26, 2019 · A single dose of ProHeart® 12 was 100% effective in preventing heartworm disease in dogs for a full year in both laboratory and field studies. The efficacy of an extended-release injectable moxidectin (0.5 mg/kg) suspension (ProHeart® 12) (PH 12) in preventing the development of Dirofilaria immitis in dogs for 12 months was ... Trazodone can be lethal if more then the prescribed dose is taken, but instances are rare, according to MedlinePlus. The average dose for an outpatient adult ranges from 150 millig... ProHeart 6 administered up to 5 times the recommended dose in 7-8 month old puppies did not cause any systemic adverse effects. In well controlled clinical field studies, ProHeart 6 was used in conjunction with a variety of veterinary products including anthelmintics, antiparasitics, antibiotics, analgesics, steroids, non-steroidal anti ... 12 chances to miss a dose! When life gets busy, it can be tough to stay on top of monthly dosing— • and many pet owners do forget.2 Dogs may vomit or spit out the chews, which means you may have to redose. Some dogs refuse to eat "treat-like Is ProHeartIndices Commodities Currencies StocksSince ProHeart 12 is new, there’s not much information about its specific side effects yet. But it uses moxidectin … the same active ingredient as ProHeart 6 … and in a higher dose. So let’s look at the history of that drug. ProHeart 6 Adverse Reactions It’sSee list of participating sites @NCIPrevention @NCISymptomMgmt @NCICastle The National Cancer Institute NCI Division of Cancer Prevention DCP Home Contact DCP Policies Disclaimer P...ProHeart 12 Dosing Chart. Heartworm disease is a serious and potentially fatal condition in dogs, caused by parasitic worms living in the heart and blood vessels of the lungs. A robust prevention strategy is crucial, and this is where ProHeart 12, an extended-release injectable suspension by Zoetis Inc., comes into play.A single dose of ProHeart® 12 was 100% effective in preventing heartworm disease in dogs for a full year in both laboratory and field studies. The efficacy of an extended-release injectable moxidectin (0.5 mg/kg) suspension (ProHeart® 12) (PH 12) in preventing the development of Dirofilaria immitis in dogs for 12 months was ...ProHeart 6 administered at 3 times the recommended dose did not adversely affect the reproductive performance of male or female dogs. ProHeart 6 administered up to 5 times the recommended dose in 7-8 month old puppies did not cause any systemic adverse effects.ProHeart 12 is indicated for use in dogs 12 months of age and older for the accurate dosing calculate each dose based on the dog's weight at the time ... proheart pi ProHeart® 6(moxidectin) ProHeart 6 is indicated for use in dogs six months of age and older for the calculate each dose based on the dog's weight at the time of treatment. proheartcis piheartworm preventive product, ProHeart 6 should be given within one month of the last dose of the former medication. ProHeart 6 eliminates the larval and adult stages of A. caninum and U. stenocephala present at the time of treatment. However, persistentandIndices Commodities Currencies StocksWhy monthly dosing is a risky option Recent survey studies conducted in the United States have revealed that of those patients not receiving the annual Proheart heartworm injection, only 75% are on a monthly preventative. Of these owners giving monthly ...A Dose of Relief: The Cytopoint Dosing Chart. Cytopoint’s dosing is based on weight, and it’s administered via a subcutaneous injection. Key Takeaways: Cytopoint is tailored to your dog’s weight. A combination of vials may be required for a single dose. Repeat treatments every 4-8 weeks, or as needed.Microdosing is typically defined by experts as taking 5 percent to 10 percent of a full dose of a psychedelic, usually LSD or psilocybin, as a way to get the supposed mental health benefits of the ...ProHeart offers convenience with less frequent dosing, while Simparica Trio appeals to those who prefer oral administration. Round 3: Safety and Side Effects Both medications have demonstrated safety in numerous studies, but as with all treatments, side effects can occur.ProHeart 12 prevents the development of heartworm disease caused by D. immitis for 12 months. For dogs not previously on heartworm preventive or having lapsed beyond 12 months of a prior ProHeart 12 dose, the product should be given within 1 month of exposure to mosquitoes. Follow-up treatments may be given every 12 months,ProHeart 6 is indicated for use in dogs six months of age and older for the prevention of heartworm disease caused by Dirofilaria immitis for 6 months. ProHeart 6 is indicated for the treatment of existing larval and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections. ProHeart 6 (moxidectin) Dosage And Administrationtheir dose – first dose – if you're in a shelter, no ... which is ProHeart 6. Are any of you guys using ... careful when you're dosing herding breeds with it.Indices Commodities Currencies StocksSee list of participating sites @NCIPrevention @NCISymptomMgmt @NCICastle The National Cancer Institute NCI Division of Cancer Prevention DCP Home Contact DCP Policies Disclaimer P...ProHeart 12 prevents the development of heartworm disease caused by D. immitis for 12 months. For dogs not previously on heartworm preventive or having lapsed beyond 12 months of a prior ProHeart 12 dose, the product should be given within 1 month of exposure to mosquitoes. Follow-up treatments may be given every 12 months,Missing a dose of either ProHeart or Simparica Trio can momentarily weaken the protective barrier against parasites. In the event of a missed dose of Simparica Trio, the immediate administration of the medication as soon as it’s remembered, followed by the resumption of the monthly schedule, is advised to maintain its efficacy against …The lethal dose of diphenhydramine, the generic name of Benadryl, varies significantly from person to person because of differences in weight and metabolism.Amphetamine: learn about side effects, dosage, special precautions, and more on MedlinePlus Amphetamine can be habit-forming. Do not take a larger dose, take it more often, or take...These two charts compare current heartworm preventive products side by side to assist you in determining which is right for your situation. In the second chart, LD50 stands for lethal dose to 50 percent of a population. Typically lethal doses are expressed as oral (toxin taken by mouth) or by dermal (toxin placed on the skin).Medicine Matters Sharing successes, challenges and daily happenings in the Department of Medicine ARTICLE: Absence of Humoral Response After Two-Dose SARS-CoV-2 Messenger RNA Vacci...ProHeart 12 prevents the development of heartworm disease caused by D. immitis for 12 months. For dogs not previously on heartworm preventive or having lapsed beyond 12 months of a prior ProHeart 12 dose, the product should be given within 1 month ofProHeart 12 is a medication that prevents heartworm disease in dogs 12 months of age and older. Your veterinarian gives it to your dog via an injection and it protects your dog from developing heartworm disease for 12 full months. ProHeart 12 also treats common hookworm infections your dog may have at the time of injection.ProHeart 12 was dosed at 0.5 mg/kg body weight (1X, five dogs), 1.5 mg/kg body weight (3X, five dogs), or 2.5 mg/kg body weight (5X, five dogs). No clinical signs of moxidectin toxicity were observed during the 42-day study. Heartworm-Positive Safety: In a laboratory study, 16 Beagle dogs implanted with adult heartworms. ProHeart 12 prevents the development of heartworm disease caused by D. immitis for 12 months. For dogs not previously on heartworm preventive or having lapsed beyond 12 months of a prior ProHeart 12 dose, the product should be given within 1 month of exposure to mosquitoes. Follow-up treatments may be given every 12 months, ProHeart 12 prevents the development of heartworm disease caused by D. immitis for 12 months. For dogs not previously on heartworm preventive or having lapsed beyond 12 months of a prior ProHeart 12 dose, the product should be given within 1 month ofIn a well-controlled 605-day US field study, two doses of ProHeart 12 were administered subcutaneously at a dosage of 0.5 mg/kg (0.23 mg/lb), 12 months apart. A total of 235, 226 and 222 ProHeart 12-treated dogs completed the heartworm testing (adult None ...ProHeart 6 should be given within one month of the last dose of the former medication. ProHeart 6 eliminates the larval and adult stages of A. caninum and U. stenocephala present at the time of treatment. However, persistent effectiveness has not been ProHeart® FAQ. Lakeside Animal Clinic is happy to offer ProHeart ® 6 and ProHeart® 12, an injectable heartworm prevention administered every six or twelve months. It is a safe, effective, convenient, and economical way to prevent heartworms. If you've ever forgotten to give your dog his or her monthly heartworm prevention, then ProHeart® 6 ... PHT-00009. ProHeart® 6 (moxidectin) delivers 6 months of heartworm disease prevention for dogs with 1 shot. Learn more here.The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.ProHeart 6 is a heartworm preventive and hookworm treatment for dogs six months and older. Learn how to mix, measure and administer the subcutaneous injection, and follow …SIGN-IN FOR REGISTERED USERSProHeart 6 administered at 3 times the recommended dose did not adversely affect the reproductive performance of male or female dogs. ProHeart 6 administered up to 5 times the recommended dose in 7-8 month old puppies did …The ProHeart debate. In January, the Food and Drug Administration's Veterinary Medicine Advisory Committee and consultants heard presentations by the FDA Center for Veterinary Medicine and Fort Dodge Animal Health on the safety of ProHeart 6 (sustained release injectable moxidectin). This past September, Fort Dodge voluntarily … ProHeart 12 Prescribing Information. ProHeart® 6 (moxidectin) delivers 6 months of heartworm disease prevention for dogs with 1 shot. Learn more here. Client Information Sheet. Review this information with your veterinarian each time your dog receives ProHeart 6. When your veterinarian prescribes medicine for your dog, it’s sometimes hard to remember all the information discussed during the visit. This sheet is provided as a summary, but if. you have any additional questions you should ...Jul 12, 2023 ... The only difference between Proheart 6 and 12 is the dose. IIRC it's just double the dose of Proheart 6. Upvote 1. Downvote Reply replyChart dosage directions package older children dosing What to do when your child is sick Proheart dosing chart Proheart® 12 (moxidectin)for extended-release injectable suspension for dogs Proheart 12 Dosing Chart Proheart-12-proheart-6 …ABN 94 156 476 425. Level 6, 5 Rider Blvd. Rhodes NSW 2138 AUSTRALIA Tel: 1800 814 883 Fax: (02) 8876 0444 Email: [email protected]. Chemical nature: Moxidectin as inert microspheres. Trade Name: ProHeart® SR-12 Injection Once-A-Year Heartworm Preventative for Dogs. Other Names:Medicine Matters Sharing successes, challenges and daily happenings in the Department of Medicine ARTICLE: Valganciclovir Dosing for Cytomegalovirus Prophylaxis in Solid-organ Tran...One COVID-19 vaccine is already under review for possible emergency authorization in December; its competitors are close behind. Once we have a vaccine—or maybe several—it will be ... ProHeart 12 is an extended-release injectable formulation of moxidectin for dogs 12 months of age or older. It protects against heartworm disease and other parasites for 12 months with one dose. Jul 9, 2018 ... ... proheart early or late up to 2 weeks after ... what I would do if your dog misses a dose, dose ... dosing day and dose again in 30 days or whatever ...Smoothies are a great way to get your daily dose of fruits and vegetables, while also enjoying a delicious and refreshing drink. Whether you’re looking for a healthy breakfast or a...PHT-00009. ProHeart® 6 (moxidectin) delivers 6 months of heartworm disease prevention for dogs with 1 shot. Learn more here.Cardio Pro is a comprehensive formula featuring 12 active ingredients that support cardiovascular health and function in dogs and cats.The second ProHeart 12 dose and the additional eight Heartgard Plus doses provided heartworm prevention during this period. Of the 236 dogs that received two annual doses of ProHeart 12, no animals tested positive for the presence of heartworm antigen or circulating MF at any time during this study, indicating complete heartworm …PHT-00009. ProHeart® 6 (moxidectin) delivers 6 months of heartworm disease prevention for dogs with 1 shot. Learn more here.Does your "3 mg" gummy actually contain 10 milligrams of melatonin? According to a recent study, it might. If you’ve ever felt like your melatonin gummies hit harder than you expec...PHT-00009. ProHeart® 6 (moxidectin) delivers 6 months of heartworm disease prevention for dogs with 1 shot. Learn more here.In a well-controlled 605-day US field study, two doses of ProHeart 12 were administered subcutaneously at a dosage of 0.5 mg/kg (0.23 mg/lb), 12 months apart. A total of 235, 226 and 222 ProHeart 12-treated dogs completed the heartworm testing (adult heartworm antigen and microfilariae) on Days 365, 480 and 605, respectively.ProHeart 12 prevents the development of heartworm disease caused by D. immitis for 12 months. For dogs not previously on heartworm preventive or having lapsed beyond 12 months of a prior ProHeart 12 dose, the product should be given within 1 month ofProHeart 6 is indicated for use in dogs six months of age and older for the prevention of heartworm disease caused by . Dirofilaria immitis. for 6 months. ProHeart 6 is indicated for the treatment of existing larval and adult hookworm (Ancylostoma caninum. and . Uncinaria stenocephala) infections. DOSAGE AND ADMINISTRATION
ProHeart 6, an extended-release injectable suspension using the exact same formulation as ProHeart 12 but at one-third the dose (0.17 mg/kg) of ProHeart 12, was 99.5% effective against the same JYD-34 strain, when treatment was administered 2 …. O'reilly scotts valley
Dose. ProHeart 12 Dosing Chart. Heartworm disease is a serious and potentially fatal condition in dogs, caused by parasitic worms living in the heart and …ProHeart 6 and ProHeart 12 See Prescribing Information for ProHeart 6 and ProHeart 12. Use ProHeart 6 in dogs 6 months of age or older and ProHeart 12 in dogs 12 months of age or older. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug.However, none of these products, except ProHeart® 6 and ProHeart® SR-12 reported here, has demonstrated microfilaricidal potency against a resistant heartworm isolate. A product that has the ability to reduce MF levels of resistant strains substantially could be useful in reducing the overall risk of transmission of these strains in a natural …ProHeart 12 prevents the development of heartworm disease caused by D. immitis for 12 months. For dogs not previously on heartworm preventive or having lapsed beyond 12 months of a prior ProHeart 12 dose, the product should be given within 1 month ofProheart 6, Proheart 12. every 6 months for Proheart 6, every 12 months for Proheart 12. yes. yes. No, in fact, owner must agree to pre-treatment labwork including heartworm testing. Proheart 6. 263 mg/kg in the rat when given by injection (the dose used therapeutically is 0.17mg/kg) Trifexis. monthly• ProHeart 12 contains 3 times the dose of moxidectin microspheres in ProHeart 6. • ProHeart 6 is for use in dogs 6 months of age or older while ProHeart 12 is for use in dogs 12 months of age ... ProHeart 12 prevents the development of heartworm disease caused by D. immitis for 12 months. For dogs not previously on heartworm preventive or having lapsed beyond 12 months of a prior ProHeart 12 dose, the product should be given within 1 month of exposure to mosquitoes. Follow-up treatments may be given every 12 months, Dose promptly after drawing into dosing syringe. If administration is delayed, gently roll the dosing sy ringe prior to injection to maintain a uniform suspension and accurate dosing. Using aseptic technique, inject the product subcutaneously in the left or right side of the dorsum of the neck cranial to the s capula. ProHeart® FAQ. Lakeside Animal Clinic is happy to offer ProHeart ® 6 and ProHeart® 12, an injectable heartworm prevention administered every six or twelve months. It is a safe, effective, convenient, and economical way to prevent heartworms. If you've ever forgotten to give your dog his or her monthly heartworm prevention, then ProHeart® 6 ... If people skip their second doses, or even if they delay them, it gives the coronavirus more chances to mutate and become resistant to the Covid-19 vaccines we have. On Jan. 16, In...ProHeart 6 administered at 3 times the recommended dose did not adversely affect the reproductive performance of male or female dogs. ProHeart 6 administered up to 5 times the recommended dose in 7-8 month old puppies did not cause any systemic adverse effects.ABN 94 156 476 425. Level 6, 5 Rider Blvd. Rhodes NSW 2138 AUSTRALIA Tel: 1800 814 883 Fax: (02) 8876 0444 Email: [email protected]. Chemical nature: Moxidectin as inert microspheres. Trade Name: ProHeart® SR-12 Injection Once-A-Year Heartworm Preventative for Dogs. Other Names:ProHeart 12 prevents the development of heartworm disease caused by D. immitis for 12 months. For dogs not previously on heartworm preventive or having lapsed beyond 12 months of a prior ProHeart 12 dose, the product should be given within 1 month of exposure to mosquitoes. Follow-up treatments may be given every 12 months,Dec 16, 2006 ... effectiveness of ProHeart 6 indicates that full ... at the recommended dosing rate appeared to ... ProHeart 6 was withdrawn from the market.Smoothies are a great way to get your daily dose of fruits and vegetables. They’re easy to make, delicious, and can be enjoyed at any time of the day. If you’re a beginner looking ...FULL YEAR. 1. Get off to a great start with these3 steps for success. STEP. TRAIN. • Make sure your team understands that ProHeart 12 is your practice’s choice for continuous heartworm disease prevention in dogs • Schedule training with … The first dose of ProHeart should be given to dogs in accordance with the label. ProHeart 6 is indicated for healthy dogs at least 6 months of age or older. ProHeart 12 is indicated for healthy dogs at least 12 months of age or older. heartworm preventive product, ProHeart 6 should be given within one month of the last dose of the former medication. ProHeart 6 eliminates the larval and adult stages of A. caninum and U. stenocephala present at the time of treatment. However, persistent andProHeart 6 should be given within one month of the last dose of the former medication. ProHeart 6 eliminates the larval and adult stages of A. caninum and U. stenocephala present at the time of treatment. However, persistent efectiveness has not been established for this indication. Re-infection with A. caninum and U. stenocephala may occur• ProHeart 12 contains 3 times the dose of moxidectin microspheres in ProHeart 6. • ProHeart 6 is for use in dogs 6 months of age or older while ProHeart 12 is for use in dogs 12 months of age ....
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